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KMID : 0356919940270020136
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Korean Journal of Anesthesiology
1994 Volume.27 No. 2 p.136 ~ p.142
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The Effect of Continuous Intravenous Infusion of Esmolol on the Hemodynamic Changes Following Endortracheal Intubation.
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Abstract
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The changes in heart rate, systolic, mean and diastolic arterial blood pressure, and the plasma concentration of epinephrine and norepinephrine were measured before and throughout the induction periods of anesthesia in 60 elective surgical
patients
in a
randomized, double-blind manner to evaluate the effects of continuous intravenous infusion of esmolol for 1 minute at 500㎍/㎏/min as a loading dose and for 4 minutes at 100㎍/㎏/min as a maintenance dose. The control group (n=30) was given the
continuous infusion of normal saline at the same volumerate. During the study, anesthesia was maintained with N2O-O2-enflurane-vecuronium and controlled ventilation.
In the esmolol group, statistically, the heart rate at 1 minute after the intubation was less increased and systolic and diastolic pressure after 11 minutes were more decreased than the control group. And plasma norepinephrine concentration was
elevated
more than the control group at 3 minutes after the intubation.
We concluded that the used infusion rate of esmolol blunted the hemodynamic changes following the laryngoscopy and endotracheal intubation but it is still needed to find the dosage for complete blocking the adrenergic response.
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